Momordica 4:1 Extract – The liquid and powdered extract of different parts of Momordica sp., administered orally produces favorable blood sugar levels in the bloodstream. When the glucose tolerance tests were carried out, blood sugar level declined during the initial 1 hour and 15 minutes in all subjects who were given the Momordica extract.The extract concentrate from the leaves of Momordica in varying doses was reported to produce blood sugar lowering properties in normal and diabetic fasting individuals, the fall being gradual and steady for 4 hours and then recovering slowly. In a trial 8 patients took 10cc, three times a day of Momordica extract. The following table shows the glucose levels after 60 days when it appeared to stabilize.
Several mechanisms by which cinnamon might lower glucose have been proposed. Cinnamon may have an insulin-like effect, causing glucose to be stored in the form of glycogen. In one study of rats, cinnamon reportedly caused an increase in glucose receptor activity in the cells which is responsible for increasing glucose uptake in muscle tissue. Cinnamon has also been reported to cause an increase in the transporter mechanisms that take glucose out of the blood stream and into tissue.
In a person with normal metabolism, insulin is secreted from the pancreas after eating. Insulin signals fat and muscle cells to absorb glucose from the blood by binding to the insulin receptor on the surface of fat and muscle cells.)
Cinnamon has also been cited as having a number of other properties that might contribute to any blood sugar lowering effect that it might have. A study published in the journal Diabetes Care in 2003 looked at 60 men and women with blood sugar issues. The participants took 1, 3, or 6 grams of Cassia cinnamon or a placebo, in capsule form, for 40 days. After this time, blood glucose levels dropped between 18% and 29% in all three groups that received cinnamon. However, only the participants who had taken the smallest amount of cinnamon (1 gram) continued to have improved blood glucose levels 20 days after they stopped taking it, for reasons the researchers didn’t quite understand.
In the study, cinnamon also helped lower triglycerides (a blood lipid) and LDL (or “bad”) cholesterol levels. The benefits continued after 60 days, 20 days after participants had stopped taking cinnamon.
In our first trial 10 patients took 250 mg, three times a day of a dry powder of Momordica. The following table shows the glucose levels after the first 10 days when it appeared to stabilize.
Gymnema Sylvestre (75%)
Gymnemic acids present in Gymnema sylvestre have blood sugar lowering, anti-sweetener and anti-inflammatory activities. The blood sugar lowering array of molecules have been identified as a group of closely related gymnemic acids after it was successfully isolated and purified from the leaves of G. sylvestre. Later, the constituents of Gymnema sylvestre were isolated, and their chemistry and structures were studied and explained.
Gymnemic acid formulations have also been found useful against obesity, according to recent reports. This is attributed to the ability of gymnemic acids to delay the glucose absorption in the blood. The structure of gymnemic acid molecules is similar to that of glucose molecules. These molecules fill the receptor locations on the taste buds thereby preventing its activation by sugar molecules present in the food, thereby curbing the sugar craving. Similarly, Gymnemic acid molecules fill the receptor location in the absorptive external layers of the intestine thereby preventing the sugar molecules absorption by the intestine, which results in low blood sugar level.
Gymnema leaf extract has been found to interfere with the ability of the taste buds on the tongue to taste sweet and bitter. Gymnemic acid has a similar effect. It is believed that by inhibiting the sweet taste sensation, people taking it will limit their intake of sweet foods and this activity may be partially responsible for its known hypoglycemic effect
The gymnemic acid in the leaves of Gymnema sylvestre and have been shown to block sweet taste in humans making sweet foods less palatable and contributing to curb appetite.
Chromium Polynicotinate is a form of niacin bound chromium that has significantly increased bioavailability and biological activity. The niacin bound chromium has been shown to be several times more biologically active than other forms of chromium. Chromium works in the body by enhancing the activity of insulin in the uptake and metabolism of blood sugar. Through this mechanism of action, chromium has been shown to help stabilize blood sugar which is very important for diabetics, hypoglycemic individuals and anyone who experiences sugar cravings due to blood sugar irregularities. Chromium also helps inhibit sugar-induced high blood pressure through the regulation of blood sugar levels. Research has also shown significant improvements in serum cholesterol levels while improving the ratio of good cholesterol to bad cholesterol.